Tissue distribution of cefotetan in the field of obstetrics and gynecology
Nishino, H.; Nagamatsu, M.; Ishii, S.; Takamatsu, S.; Saito, J.; Yamanaka, K.
Japanese Journal of Antibiotics 36(2): 398-407
1983
ISSN/ISBN: 0368-2781 PMID: 6574265 Document Number: 214682
The concentrations of cefotetan (CTT) in serum, uterus, ovary and oviduct tissues were determined in 30 patients after single intravenous drip infusion of 1 g over 1 hour. 1. Peripheral blood level of CTT was determined from 3 to 24 hours after injection. The maximum level was observed at 3 hours after injection and the concentration went down gradually with time. 2. The tissue concentrations of CTT in intrapelvic organs also tended to decrease with time and hardly detected 24 hours after injection. 3. From 3 to 12 hours after injection, mean penetration rate of CTT into intrapelvic organs was 40% and more. 4. Among intrapelvic organs, penetration rate into portio was highest, and others were ovary, uterine cervix, oviduct, endometrium, myometrium and uterine myoma in order of lowering penetration rate. 5. The penetration rate into uterine myoma was approximately half that into normal tissue. Considering above results, CTT is expected to show sufficient effects against Gram-negative bacilli and Bacteroides sp. when reasonably dosed.