Serological response of cattle following Brucella abortus strain 19 vaccination and simultaneous administration of levamisole
Chukwu, C.C.
International Journal of Zoonoses 12(3): 196-202
1985
ISSN/ISBN: 0377-0168 PMID: 3938779 Document Number: 265915
The serological response of heifers to injection with Brucella abortus strain 19 vaccine and simultaneous administration of levamisole hydrochloride were compared with those of heifers inoculated with Brucella abortus strain 19 vaccine alone. The Rose Bengal, serum agglutination, complement fixation and Coombs' antibovine globulin tests were used to measure the humoral responses for a period of sixteen weeks after vaccination. The results indicated that antibody titers in the heifers injected with levamisole and the vaccine were moderately elevated. It was suggested that the heightened antibody titres were possibly mediated through helper T-cells and macrophages. The significance of using levamisole as an adjuvant with Brucella abortus strain 19 vaccine in cattle is briefly discussed.