Study on the prostatic tissue levels of cefmenoxime (CMX)
Kataoka, K.; Kaneko, S.; Kurita, T.
Hinyokika Kiyo. Acta Urologica Japonica 31(2): 273-279
1985
ISSN/ISBN: 0018-1994 PMID: 2409786 Document Number: 250485
The concentrations of cefmenoxime (CMX) were examined in the serum and prostatic tissue of 25 patients with benign prostatic hypertrophy and of 1 patient with prostatic carcinoma. The CMX levels were measured at scheduled intervals after 2 g CMX administration by 1 h drip infusion prior to prostatectomy. Pharmacokinetic analysis was performed based on the 2 compartment open model theory. Maximum serum level of CMX was 124 .mu.g/ml at the end of drip infusion and the biological half-life was 1.07 h. CMX concentration in prostatic tissue reached a maximum level of 35.7 cg/g at 1.16 h after the start of CMX administration. Ratio of prostatic tissue to serum level in the area under curve (AUC) was 33% and biological half-life was 107 h. Apparently the CMX concentration in the prostatic tissue was higher than th MIC80 against pathogenic bacteria, particularly Escherichia coli and Klebsiella sp., for a relatively long time. For this reason CMX is one of the more preferred drugs for treatment of chronic prostatitis and post-operative infection of prostate.