Study on the absorption of ketoprofen topically administered in man: comparison between tissue and plasma levels
Ballerini, R.; Casini, A.; Chinol, M.; Mannucci, C.; Giaccai, L.; Salvi, M.
International Journal of Clinical Pharmacology Research 6(1): 69-72
1986
ISSN/ISBN: 0251-1649 PMID: 3957503 Document Number: 549
In this study the transcutaneous passage of ketoprofen (gel) topically administered and its distribution in the inner part of the knee-joint were evaluated in six patients. The ketoprofen concentrations detected were: 4.70 mcg/g .+-. 3.87 in the intra-articular adipose tissue; 2.35 mcg/g .+-. 2.41 in the capsular sample and 1.31 mcg/g .+-. 0.89 in the synovial fluid. Plasma concentrations of the drug were also examined. In the samples studied, the ketoprofen levels amounted to about one hundred times higher than the plasma concentrations.
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