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Comparison of serum and prostatic levels of tobramycin

Bismuth, R.; Fredj, G.; Khoury, S.; Rigat, B.

Pathologie-Biologie 32(5 Part 2): 511-515

1984

ISSN/ISBN: 0369-8114
PMID: 6379568
Document Number: 241670
In 19 patients with various prostatic diseases, serum and prostatic tissue levels of tobramycin were determined by bioassay and enzyme immunoassay after 1, 3 or 4 intramuscular injections of 75 mg tobramycin. The last injection was given ninety minutes prior to prostatectomy. Mean serum and prostatic tissue levels were respectively 3.55 micrograms/ml and 1.70 micrograms/g by bioassay, and 3.55 micrograms/ml and 2.37 micrograms/g by enzyme immunoassay. There was no significant difference in prostatic tissue levels between patients who received 3 or 4 drug doses and those who received one dose. Prostatic tissue levels were not significantly different in adenoma and chronic prostatitis.

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