Pharmacokinetic study of cefmenoxime concerning its transfer into tissues
Washida, H.; Tsugaya, M.; Hirao, N.; Sakagami, H.; Iwase, Y.
Japanese Journal of Antibiotics 38(6): 1648-1653
1985
ISSN/ISBN: 0368-2781 PMID: 3862883 Document Number: 255994
Cefmenoxime (1 g) was intravenously administered by one shot to investigate its pharmacokinetic profile with respect to transfer into the kidney, vesical wall and prostatic adenoma. The concentration of cefmenoxime in the kidney reached a peak of 403 micrograms/g at 0.17 hour after administration. The biological half-life was 0.74 hour. In the vesical wall, the level of cefmenoxime reached a peak of 28 micrograms/g at 0.67 hour after administration. The half-life was 2.30 hours. The peak level of cefmenoxime in the prostatic adenoma was 22 micrograms/g at 0.39 hour after administration. The half-life was 2.90 hours. The concentrations of cefmenoxime in these urogenital tissues were higher than its MIC80 and MBC80 against various Gram-negative organisms.