Effect of different interferon preparations on the synthesis of cellular DNA
Malinovskaia, V.V.; Litovchenko, V.G.
Voprosy Virusologii 30(4): 417-419
1985
ISSN/ISBN: 0507-4088 PMID: 2414926 Document Number: 242910
The relationship between the age of interferon producers and the capacity of interferon to inhibit DNA synthesis in L929 cells was demonstrated on interferon models produced by fibroblast cultures from newborn and adult mice in the presence of blood sera of hemologous ages. Inhibition of DNA synthesis by both types of interferon partially purified with the use of porous glass and having similar antiviral activity depended both on the dose of the preparation and on the time of cell incubation with it. Under equal conditions, the interferon produced by newborn mouse cells inhibited DNA synthesis 1.9-fold less effectively than interferon produced by adult mouse cells.