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Potentiation of antitumor effect of virus-induced interferon by mouse immune interferon preparations

Fleischmann, W.R.; Kleyn, K.M.; Baron, S.

Journal of the National Cancer Institute 65(5): 963-966

1980

ISSN/ISBN: 0027-8874
PMID: 6159498
Document Number: 167797
In inbred DBA/2 mice, the antitumor activities of separate and combined preparations of mouse immune interferon and mouse virus-induced interferon on the development of P388 tumors were studied. Immune interferon alone (25 U/day) did not affect tumor development. Virus-induced interferon alone (25,000 U/day) delayed tumor development and increased survival time. The mouse immune interferon preparations significantly enhanced or potentiated the antitumor effects of mouse virus-induced interferon when the interferons were used in combined therapy.

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