The kinetics of interferon production by mouse lymphocytes and its modulating effect of the virus plaqueforming cell assay as a quantitative method to determine activated lymphocytes
Heine, J.W.; Adler, W.H.
Journal of Immunology 117(3): 1045-1048
1976
ISSN/ISBN: 0022-1767 PMID: 182880 Document Number: 97916
The validity of the virus cells is dependent on the rate and amount of coinciding interferon production which varies with different strains of mice. The V-PFC assay demonstrates that the kinetics of cellular activation by mitogens initially involves about 0.01% of responding cells and possibly recruitment of other cells which include cells requiring a longer lag period for activation.
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