Effect of interferon on the expression of mouse mammary tumor virus (MMTV) in GR cells in culture
Chalbos, D.; Crepin, M.; Lebleu, B.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 173(6): 1124-1132
1980
ISSN/ISBN: 0037-9026 PMID: 6155982 Document Number: 159511
Interferon treatment of GR cells markedly inhibits the production of MMTV as quantitated by hybridization of its viral RNA in the cell culture medium. The level of intracellular viral RNA and its rate of synthesis are however not modified by interferon. The intracellular levels of the major viral proteins as measured by immunoprecipitation remain unchanged. The intracellular level of the viral reverse transcriptase activity is reduced by about 40% as compared to more than 95% in the cell culture medium.