The action of interferon preparations on strains of Legionella of various serogroups and species
Tartakovskiĭ, I.S.; Marakusha, B.I.; Kuznetsov, V.V.; Nebozhina, L.V.; Prozorovskiĭ, S.V.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 104-106
1988
ISSN/ISBN: 0372-9311 PMID: 2469268 Document Number: 311186
The action of different preparations of interferon on Legionella strains has been studied in vivo and in vitro. The preparations of leukinferon at a concentration of 500 international units (I.U.) and reaferon at a concentration of 10,000 I.U. have been found to produce an inhibiting effect on Legionella strains in vitro, in a medium with carbon-yeast agar. Leukinferon at a concentration of 125 I.U. suppresses the growth of L. pneumophila also in a liquid medium. The preparation of leukinferon at a minimal concentration of 100 I.U. has been found to suppress the development of lethal infection in chick embryos infected with L. pneumophila strain Philadelphia 1.