Effects of midecamycin acetate (miocamycin) , a new macrolide antibiotic, on reproductive performances in rats and rabbits
Moriguchi, M.; Takeda, U.; Hata, T.; Yamamoto, A.; Koeda, T.
Japanese Journal of Antibiotics 37(8): 1572-1595
1984
ISSN/ISBN: 0368-2781 PMID: 6334185 Document Number: 239345
Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to determine the effect of MOM on reproductive performance in rats and rabbits. MOM, non-crystalline solid, was suspended in 0.1% CMC solution immediately before use. In this study, reproductive performance was studied according to the following designs: Fertility test (Segment I) in Wistar rats Teratogenicity test (Segment II) in Wistar rats Peri- and post-natal tests (Segment III) in Wistar rats Behavioral test in rat newborns in Segments II and III Teratogenicity test (Segment II) in New Zealand white rabbits In conclusion, MOM, non-crystalline solid, might have no teratogenesis and little influence on dams and their fetuses and offsprings.