Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin) . Part II-2. Subacute toxicity in rabbits
Yokota, M.; Takeda, U.; Odaki, M.; Sasaki, H.; Niizato, T.; Kawaoto, H.; Kumagai, K.; Suzuki, H.; Hayasaka, H.; Suzuki, M.
Japanese Journal of Antibiotics 37(7): 1333-1354
1984
ISSN/ISBN: 0368-2781 PMID: 6333529 Document Number: 233090
Miokamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic isolated from a culture broth of Streptomyces mycarofaciens. The objective of this study was to examine toxicological effects in male and female rabbits after repeated oral administration of MOM, non-crystalline solid, for 5 weeks at daily dosages of 400, 800, 1,600 and 3,200 mg/kg. In conclusion, the maximum non-toxic dosage level of MOM, non-crystalline solid, is presumed to be 400 mg/kg in male and female rabbits with p.o. administered once daily for 5 weeks.