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Analytical-physical profile of the novel macrolide antibiotic flurithromycin ethylsuccinate

Colombo, N.; Depaoli, A.; Gobetti, M.; Saorin, M.G.

Arzneimittel-Forschung 44(7): 850-855

1994

ISSN/ISBN: 0004-4172
PMID: 7945521
Document Number: 427582
Data are reported on the structural characterization of flurithromycin ethylsuccinate (FE, CAS 82730-23-2), a novel macrolide antibiotic UV, IR, NMR and MS spectra confirmed the structure, in particular the presence of ketonic-hemiketalic equilibrium, already described for flurithromycin A, is supported by NMR and HPLC studies. Moreover physico-chemical properties and stability were studied,- the product exhibits a good stability at solid state, whereas degradation products are present both in acidic and basic solution. Microbiological activity and principal pharmaceutical features were carried out.

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