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Study of the structural and functional properties of fibronectin--a high molecular weight plasma glycoproteins--by using monoclonal antibodies

Chernousov, M.A.; Metsis, M.L.; Glukhova, M.A.; Antonov, A.S.; Orekhov, A.N.

Molekuliarnaia Biologiia 18(3): 643-652

1984

ISSN/ISBN: 0026-8984
PMID: 6206390
Document Number: 222485
Functional and structural properties of fibronectin--high molecular weight glyco-protein from human plasma--were studied by monoclonal antibodies against fibronectin. It was shown that monoclonal antibodies against human plasma fibronectin exhibit a certain species specificity. Antigenic determinant for our monoclonal antibody is located in the central part of the protein polypeptide chain--in the structural domain. The monoclonal antibodies studied do not inhibit any tested functions of fibronectin. In contrast, polyclonal antibodies are not species specific and inhibit all fibronectin functions.

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