Preliminary studies of Conus geographus venom structural properties: evaluation of the toxin's molecular weight
Le Deaut, J.Y.; Rabesandratana, H.; Rakotovao, L.H.; Solar, S.; Zeller, H.; Coulanges, P.
Archives de l'Institut Pasteur de Madagascar 46(1): 497-506
1978
ISSN/ISBN: 0020-2495 PMID: 747445 Document Number: 126254
Venom from the posterior half of the venom duct of Conus Geographus was toxic to mice but without effect on a crab, and produced a flaccid spasmodic paralysis in mice. The minimum lethal dose for mice ranged from 5 micrograms to 50 micrograms (net weight) of venom per mouse. Toxin was submitted to Sephadex G 25 chromatography and to ultrafiltration. The venom was inactivated by pronase. The data suggested that the toxin was a peptide of molecular weight of about 1 500-2 000.