Effect of pretreatment with the alpha-adrenoblocker phentolamine and the beta-adrenoblocker inderal on the stress-induced decrease in adrenoreactivity of the portal vein
Manukhina, E.B.
Biulleten' Eksperimental'noi Biologii i Meditsiny 96(10): 62-63
1983
ISSN/ISBN: 0365-9615 PMID: 6138107 Document Number: 207001
The effect of the pretreatment with the alpha-adrenoblocker phentolamine and the beta-adrenoblocker inderal was studied on the disturbances of contractile function and adrenoreactivity which occurred after exposure to emotional-painful stress. The pretreatment of the animals exposed to emotional-painful stress with phentolamine prevented to a considerable degree the depression of portal vein contractility and raised adrenoreactivity of the smooth muscle that dramatically fell after emotional-painful stress to the basic level. Administration of inderal did not prevent the stress-induced disturbances. The data obtained suggest that the stress-induced injuring effect of catecholamine high concentrations is mediated via alpha-adrenoreceptors of portal vein smooth muscles.