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Effect of long-term myocardial unloading with beta1-adrenoblocker atenolol on the state of the left ventricle in patients with moderate ischemic dysfunction of the heart as shown by doppler echocardiography

Kaliuzhin, V.V.; Tepliakov, A.T.; Solovtsov, M.A.

Kardiologiia 42(3): 9-11

2002

ISSN/ISBN: 0022-9040
PMID: 12494178
Document Number: 548041
Effects of 12-month therapy with a beta1-adrenoblocker atenolol on the process of late postinfarction remodeling of the heart and parameters of intracardiac hemodynamics were assessed in an open noncomparative study on 55 survivors of macrofocal myocardial infarction. Therapy with atenolol was associated with: (1) reduction of myocardial hypertrophy in patients with increased left ventricular myocardial mass without effect on its volume, cavity geometry and global systolic function; (2) normalization of initially 'hypertrophic' type of transmitral blood flow. Affecting mainly the demand component of the myocardial oxygen supply/demand ratio atenolol promoted inclusion of hibernating cardiomyocytes into active contraction.

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