Influence of long-term therapy with enalapril on late postinfarction remodeling and functional state of the left ventricle in patients with diastolic heart failure.
Kaliuzhin, V.V.; Solovtsov, M.A.; Tepliakov, A.T.; Kaliuzhina, E.V.; Maleeva, M.A.; Pushnikova, E.Iu.; Kamaev, D.Iu.
Kardiologiia 46(2): 47-51
2006
ISSN/ISBN: 0022-9040 PMID: 16482043 Document Number: 599361
Enalapril (average dose 7,0+/-0.8 mg) was given for 12 weeks to 15 patients with preserved left ventricular (LV) systolic function who had survived large focal myocardial infarction small i, Ukrainian6 months before that. The use of enalapril was associated with 49% lessening of severity of clinical signs of heart failure (p<0.001) and 47% increase of tolerance to physical exercise. It also provided dose dependent 17.8% reduction of LV myocardial mass (p<0.05), normalization of initially "hypertrophic" type of transmitral flow, 21% lowering of LV end diastolic pressure (p<0.05) without effect on LV volume, geometry, global and local systolic function.