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Effects of beta 1-adrenoblocker bisoprolol on endothelial dysfunction in patients with stable angina pectoris in combination with chronic obstructive pulmonary disease

Grigor'eva, N.I.; Sharabrin, E.G.; Kuznetsov, A.N.; Mazalov, K.V.; Kontorshchikova, K.N.; Koroleva, E.F.

Terapevticheskii Arkhiv 81(3): 28-31

2009

ISSN/ISBN: 0040-3660
PMID: 19459418
Document Number: 635211
To study effects of a cardioselective beta-adrenoblocker bisoprolol on vascular wall endothelium and external respiration function in stable angina of effort combined with chronic obstructive pulmonary disease (COPD). Endothelial function and external respiration were studied before and after 4-week treatment with bisoprolol in 36 patients with stable angina and COPD using assessment of endothelium-dependent vasodilatation (EDVD) and concentrations of nitric oxide metabolites. Significant improvement of endothelial function was achieved due to bisoprolol 4-week treatment which did not affect external respiration function. Bisoprolol is effective and safe drug in the treatment of stable angina combined with COPD. It can noticeably improve endothelial function.

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