Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease
Titova, O.N.; Ignat'ev, V.A.; Didur, M.D.; Kameneva, M.Iu.; Sukhovskaia, O.A.
Terapevticheskii Arkhiv 80(3): 28-33
2008
ISSN/ISBN: 0040-3660 PMID: 18441680 Document Number: 618985
Aim. To elucidate efficacy of a combination almitrine+thiotropium bromide (TB)4pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) of stage II-III complicated with chronic respiratory failure (CRF).Material and methods. Efficacy of therapy was compared in two groups of patients: group I (n = 22) received TB in a dose 18 mcg/day for one year, almitrine in a dose 10 mg/kg/day for 3 months, an 8 week course of PR, group 2 (n = 17) received TB and PR. The treatment efficacy was determined by spirometric parameters of external respiration function, blood gases, dyspnea indices, exercise tolerance assessed by 6-min walk test, quality of life (St. George Hospital Respiratory Questionnaire).Results. Group I patients walked longer distance after a course of PR and I year later (by 90.5 +/- 25.4 and 44.5 +/- 10.2 in, respectively, p < 0.05), had reduced desaturation measured by pulsoxymetry at the end of 6-min walk test, increased PaO2 in baseline under 70 mmHg (by 5.8 +/- 1.2 mmHg, p > 0.05), decreased exacerbation rate per I patient a year (by 25916).Conclusion. Combination treatment with TB, almitrine and PR is indicated for COPD patients with moderate hypoxemia.