Use of inhibitors of the angiotensin-converting enzyme and the beta-adrenoblocker metoprolol combined in treatment of chronic cardiac insufficiency
Voronkov, L.G.; Serdiuk, T.E.; Riabenko, D.V.
Likars'ka Sprava 2000(7-8): 77-80
2000
ISSN/ISBN: 1019-5297 PMID: 16786657 Document Number: 520978
Clinical-and-hemodynamic effects were studied of a supplementary use of a selective beta-adrenoblocker metoprolol in an ongoing therapy of chronic cardiac insufficiency (CCI) with inhibitors of the angiotensin-converting enzyme (ACEI) and diuretics. It has been found out that long (over 8 weeks) course of therapy supplemented with metoprolol results in improvement of the left ventricular systolic function and lowering of the functional class. Long-term administration of metoprolol enhances tolerance to a graded physical exercise in CCI patients, which observation is accompanied by a more economic character of its performance. The findings secured validate the expediency of a supplementary use of the beta-adrenoblocker metoprolol in the routine regimen of the supporting treatment of CCI patients involving the use of ACEI plus a diuretic.