Influence of angiotensin converting enzyme inhibitors on stable myocardial ischemia in menopausal cardiac patients
Arnaout, M.S.; Khalil, A.; Alam, S.E.
Clinical and Experimental Obstetrics and Gynecology 30(1): 43-46
2003
ISSN/ISBN: 0390-6663 PMID: 12731744 Document Number: 561715
The aim of the study was to investigate the influence of angiotensin converting enzyme inhibitor (Captopril) on stable demand ischemia in menopausal cardiac female patients. In a prospective non-randomized evaluation of the effect of angiotensin converting enzymes inhibitors (ACE-I) (Captopril) on demand myocardial ischemia, 16 normotensive menopause female patients, mean age of 52 years with stable angina and known coronary artery disease (CAD) but normal left ventricular function, underwent a treadmill exercise test (Bruce Protocol), at baseline (T1) and one week following (50-75 mg) a daily dose of Captopril (CAPT2). Onset of symptoms, duration of exercise, magnitude of peak ST depression and homodynamic parameters were monitored. Captopril significantly increased the duration of exercise from (467 +/- 169 to 536 +/- 145 seconds, (p value < 0.02), but with increased peak of ST segment depression (from -1.4 +/- 0.6 mm to -1.93 +/- 1.2 mm, p value < 0.15). The double product remained unchanged (251 x 103 +/- 55 in T1 and 248 x 103 +/- 55 in CAPT2; the p value was < 0.8. All adverse effects on the treadmill were noted. Although captopril tends to significantly effect prolongation of exercise time, there is no amelioration of the markers of ischemia.