Anthelmintic activity of niclofolan and closantel against Fasciola hepatica in sheep
González, H.; Plaza, J.; Montes, G.; Pérez, R.; Toro, P.
Boletin Chileno de Parasitologia 38(3-4): 42-49
1983
ISSN/ISBN: 0365-9402 PMID: 6375690 Document Number: 203228
Seven sheep naturally infected with Fasciola hepatica were treated with niclofolan 0.8 mg/kg body weight by subcutaneous injection. 7 similar sheep were treated with closantel 2.5 mg/kg by intramuscular injection. 7 were treated with closantel 5.0 mg and 5 were held as controls. All were killed for examination 9 days later. In all the sheep the treatment was 100% effective against adult parasites. 7 further sheep were treated with closantel 5.0 mg/kg and were killed 64 days later to assess activity against immature flukes. A mean of 5.14 worms/sheep was found compared with 98.4 worms/sheep in 7 untreated controls. No statistically significant changes in blood parameters were demonstrated during this treatment.