Top Abstract Purchase Related
Home
>
Node
>
Subnode

Investigation of new benzofurane, benzopiran and furanochromone derivatives--potential antiarrhythmic and hypotensive agents

Jedrych, Z.; Borkowska, G.

Polish Journal of Pharmacology and Pharmacy 35(5): 397-403

1983

ISSN/ISBN: 0301-0244
PMID: 6664941
Document Number: 197267
Eight newly synthesized compounds were tested in respect of their acute toxicity, antiarrhythmic activity, influence on the electrogenic action of the heart and blood pressure. The most active benzofuran derivative was 2-acetyl-3-methyl-6 methoxy-7-(2'hydroxy-3'-isopropylaminopropoxy)benzofuran, the most active benzopiran: 4-methyl-6,7-dimethoxy-8-(2'-isopropylaminopropoxy)benzo-alpha- piron. Of furachromone derivatives the expected properties were displayed only by 2-methyl-5-carbamoylmethoxy-8-diisopropylaminofuro-3,2-g-chr omone.

Document emailed within 1 workday
Secure & encrypted payments

Librowski, T.; Czarnecki, R.; Jastrzebska, M. 1999: Chiral 2-amino-1-butanol xanthone derivatives as potential antiarrhythmic and hypotensive agents Acta Poloniae Pharmaceutica 56(1): 87-90
Ryczek, J.; Kusowska, J. 1983: Synthesis of 3-dialkylaminopropyl-2-thiohydant derivatives as potential antiarrhythmic agents Il Farmaco; Edizione Scientifica 38(6): 383-390
Pala, G.; Marazzi Uberti, E. 1962: A new class of hypotensive agents: 4-quinazolinone and derivatives Arzneimittel-Forschung 12: 1204-1205
Ernest, K. 1975: Pharmacology of new ethylenediamine derivatives (ROM-126, ROM-131, MK-142) with antiarrhythmic action. Part II. Antiarrhythmic properties, the influence on heart and some hemodynamic parameters Polish Journal of Pharmacology and Pharmacy 27(4): 381-398
Kunes, J.; Spulák, M.; Waisser, K.; Slosárek, M.; Janota, J. 2000: Quinoxaline derivatives as potential antituberculotic agents Die Pharmazie 55(11): 858-859
Chawla, R.; Arora, A.; Parameswaran, M.K.; Chan, P.; Sharma, D.; Michael, S.; Ravi, T.K. 2010: Synthesis of novel 1,3,4-oxadiazole derivatives as potential antimicrobial agents Acta Poloniae Pharmaceutica 67(3): 247-253
Habib, N.S.; Abdel-Hamid, S.; el-Hawash, M. 1989: Synthesis of benzimidazole derivatives as potential antimicrobial agents Farmaco 44(12): 1225-1232
Kumar L S, V. 2016: Potential use of snake venom derivatives as hemostatic agents in dentistry General Dentistry 64(1): E10-E11
Balkan, A.; Akgün, H.; Parali, N.; Ertan, M.; Açikgöz, C.; Ustaçelebi, S. 1996: New naphthyloxyalkyl beta-diketone and 3,5-dimethylisoxazole derivatives as potential antiviral agents Farmaco 51(8-9): 589-594
Rida, S.M.; Salama, H.M.; Labouta, I.M.; A-Ghany, Y.S. 1985: Synthesis of some 3-(benzimidazol-2-ylmethyl)thiazolidinone derivatives as potential antimicrobial agents Die Pharmazie 40(10): 727-728
Wu, K.M.; Zhang, M.Y.; Fang, Z.; Huang, L. 1985: Potential antileukemic agents, synthesis of derivatives of indirubin, indigo, and isoindigotin Yao Xue Xue Bao 20(11): 821-826
Ali, K.A.; Ragab, E.A.; Farghaly, T.A.; Abdalla, M.M. 2011: Synthesis of new functionalized 3-substituted [1,2,4]triazolo [4,3-a]pyrimidine derivatives: potential antihypertensive agents Acta Poloniae Pharmaceutica 68(2): 237-247
Almerico, A.M.; Diana, P.; Barraja, P.; Dattolo, G.; Mingoia, F.; Putzolu, M.; Perra, G.; Milia, C.; Musiu, C.; Marongiu, M.E. 1997: Glycosidopyrroles. Part 2. Acyclic derivatives: 1-(1,3-dihydroxy-2-propoxy)methylpyrroles as potential antiviral agents Farmaco 52(11): 667-672
Massa, S.; Stefancich, G.; Artico, M.; Corelli, F.; Silvestri, R. 1987: Potential antitumor agents. I. Synthesis of pyrroloindazole derivatives related to the pyrroloindole moieties of the antitumor antibiotic CC-1065 Il Farmaco; Edizione Scientifica 42(8): 567-574
Joshi, K.C.; Pathak, V.N.; Jain, S.K. 1980: Studies of potential organo-fluorine antibacterial agents. Part 5: Synthesis and antibacterial activity of some new fluorine-containing indole-2,3-dione derivatives Die Pharmazie 35(11): 677-679
Eckstein, M.; Zajaczkowska, J.; Samochowiec, L. 1988: (RS), (R)(-) and (S)(+) derivatives of 2-N-arylalkylamino-1-butanol having antiarrhythmic properties Polish Journal of Pharmacology and Pharmacy 40(4): 401-411
Ranise, A.; Bondavalli, F.; Mariani, E.; Schenone, P.; Lampa, E.; Giordano, L.; Vacca, C.; Marmo, E. 1983: Derivatives of 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane with hypotensive activity. Ii Il Farmaco; Edizione Scientifica 38(11): 884-892
Lukasiak, J.; Radecki, A.; Jamrógiewicz, Z. 1977: Silicone derivatives of medicinal agents. XI. Methylsilyl derivatives of methyl and propyl p-hydroxybenzoate Acta Poloniae Pharmaceutica 34(6): 615-620
Boni, P.; Bacciarelli, C. 1974: Pharmacological study of new ethylenediamine derivatives with antiarrhythmic activity Il Farmaco; Edizione Scientifica 29(12): 923-935
Ignat'ev, M.V. 1979: Hypotensive agents Fel'dsher i Akusherka 44(6): 41-43