Derivatives of 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane with hypotensive activity. Ii
Ranise, A.; Bondavalli, F.; Mariani, E.; Schenone, P.; Lampa, E.; Giordano, L.; Vacca, C.; Marmo, E.
Il Farmaco; Edizione Scientifica 38(11): 884-892
1983
ISSN/ISBN: 0430-0920 PMID: 6653774 Document Number: 216680
The synthesis of a series of alkyl and aryl ureas (II) starting from 1,3,3-trimethyl-6-azabicyclo[3.2.1]octane is described. Some of these compounds showed a moderate hypotensive activity in rats. Effects on heart rate in rats, infiltration anesthesia and antiarrhythmic activity in mice, as well as antiacetylcholine activity in vitro, are also reported.
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