(RS) , (R) (-) and (S) (+) derivatives of 2-N-arylalkylamino-1-butanol having antiarrhythmic properties
Eckstein, M.; Zajaczkowska, J.; Samochowiec, L.
Polish Journal of Pharmacology and Pharmacy 40(4): 401-411
1988
ISSN/ISBN: 0301-0244 PMID: 3222179 Document Number: 307072
A series of theophyllinyl-7'-ethyl derivatives of (RS), (R)(-) and (S)(+) 2-aminobutanol were synthesized and tested in various models of experimental arrhythmia for their preventive and curative properties; (R)(-) 2-N-theophyllinyl-7'-ethyl amino-1-butanol (1a) and (R)(-) theophyllinyl-7'-ethyl-2-N-methylamino-1-butanol (3a) hydrochlorides showed interesting antiarrhythmic properties. The levorotatory compounds of R configuration showed stronger protective and also therapeutic effect in different experimental arrhythmias.