Comparative study of beta-adrenoreceptors of rat brain synaptic membranes
Aksentsev, S.L.; Okun', I.M.; Miliutin, A.A.; Beliaeva, E.I.; Konev, S.V.
Biofizika 27(1): 156-158
1982
ISSN/ISBN: 0006-3029 PMID: 6279169 Document Number: 184819
Affinity of beta-adrenoreceptors in the rat brain synaptic membranes to agonists isoproterenol and norepinephrine, as well as to antagonist 125I-hydroxybenzylpindolol is lower in young (1 month) and old (24--26 months) than in mature (8--12 months) rats. Desensitization toward isoproterenol is expressed in the young ones only. In the old but not in other groups simultaneous action of isoproterenol and N-ethylmaleimide decreases the following binding of the antagonist while the same agents added separately produced no effect. It is suggested that beta-adrenoreceptors undergo age-related changes in their conformational state due to modification of the membrane environment.