Beta-adrenoreceptors on the surface membranes of lymphocytes and macrophages
Kozlov, V.K.; Arkhangel'skaia, S.L.; Vasil'eva, E.F.
Biulleten' Eksperimental'noi Biologii i Meditsiny 85(6): 723-725
1978
ISSN/ISBN: 0365-9615 PMID: 208686 Document Number: 133861
In experiments in vivo and in vitro on sensitized and intact guinea pigs and Wistar rats the effect of beta-adrenergic stimulants (adrenaline and izoproterenol) and a beta-adrenergic blocker (propranalol) on lymphocytolysis and the reaction of macrophage adherence inhibition was studied. Adrenaline and izoproterenol were shown to inhibit the antigen interaction with both sensitized and intact cells. Restoring the sensitivity of cells to the antigen, propranalol destroys the defensive action of adrenaline and isoproterenol.