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Change in cerebral beta-adrenoreceptors in experimental neurosis

Libe, M.L.; Brusovanik, V.I.; Levshina, I.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 115(4): 356-358

1993

ISSN/ISBN: 0365-9615
PMID: 8049389
Document Number: 415478
Pathological and adaptive-compensatory alterations of rat cerebral cortical beta-adrenergic receptors have been demonstrated using the model of experimental neurosis developing as a result of chronic emotional painful stress. After the first week of stress increases of both Kd and Bmax occur; both indexes reach control levels after 3 weeks of neurotization. The changes of cortical beta-adrenoreceptors accompany transient fall of cholesterol-to-phospholipid ratio and decrease of free radical lipid oxidation in brain cortex. The normalization of all cerebral parameters after 3 weeks of stress coincides with the activation of lipid peroxidation in blood serum.

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