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Influence of psychotropic substances on elaboration of a defensive conditioned reflex in experimental neurosis

Burov, I.V.; Speranskaia, N.P.

Biulleten' Eksperimental'noi Biologii i Meditsiny 83(6): 696-698

1977

ISSN/ISBN: 0365-9615
PMID: 560227
Document Number: 113714
Neurosis resulting in alteration of the motor-defense conditioned reflex development occurred in rats subjected to a long-term action of a negative-emotional factor--neighbour-rat's reaction to pain. Benactyzine, diazepam, chlordiazepoxide, and sodium hydroxybutyrate improved the formation of defense conditioned reflex during this form of neurosis. Trioxazin, trifluoperazine, and amphetamine produced no such effect. The proposed model of experimental neurosis can be used to reveal the tranquilizing activity of psychotropic drugs.

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