Role of the alpha- and beta-adrenoreceptors of the midbrain tegmentium in the regulation of the functions of the supraoptic-hypophyseal neurosecretory system
Popovichenko, N.V.; Chebotareva, L.L.
Fiziolohichnyi Zhurnal 23(5): 645-652
1977
ISSN/ISBN: 0015-3311 PMID: 199470 Document Number: 122282
In chronic experiments male Wistar rats with cannulas implanted into the midbrain tegmentum were subjected to short-term painful stimulation preceded by microinjections of phenoxybenzamine or inderal. The reaction of the supraoptic neurohypophyseal system (SNS) and changes in the level of vasopressin-antidiuretic hormone in blood plasma showed significant inhibition of the SNS reaction to the pain under .alpha.-adrenoreceptor blockade. Changes in the functional SNS activity during .beta.-adrenorecptor blockade were shorter and less pronounced. Activating influences on the SNS during stress might be predominantly mediated by .alpha.-adrenoreceptors of the midbrain tegmentum.