Reaction of the Gomori-positive hypothalamo-hypophyseal neurosecretory system of the rat to a single dose of thyroliberin
Krasnovskaia, I.A.; Tavrovskaia, T.V.
Problemy Endokrinologii 27(3): 48-52
1981
ISSN/ISBN: 0375-9660 PMID: 6170057 Document Number: 179052
A decrease in the functional neurosecretory cell activity of the rat hypothalamic supraoptical and paraventricular nuclei was seen 30 minutes after a single intramuscular thyroliberin injection (8 micrograms). The size of the neurosecretory cell nucleoli significantly diminished in both centers, while a large amount of intranuclear nucleoli-like bodies appeared in the paraventricular nucleus. The neurosecretory substance content in the posterior hypophysis significantly decreased, indicating an active neurohormone excretion. A possibility of negative feedback between the body thyroliberin level and the state of the Gomori-positive hypothalamic neurosecretory centers is discussed.