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The hypothalamo-hypophyseal neurosecretory system in rats with hereditary arterial hypertension

Iurisova, M.N.; Markel', A.L.; Naumenko, E.V.

Arkhiv Patologii 51(10): 40-45

1989

ISSN/ISBN: 0004-1955
PMID: 2610603
Document Number: 329327
Histochemical and cytometrical analysis of the peptidergic Gomori-positive or hypothalamo-hypophyseal neurosecretory system (HHNS) was made in the 3 strains of rats: spontaneously hypertensive rats (SHR), rats with inherited stress-induced arterial hypertension (ISIAH), and normotensive Wistar rats. A significant increase in the production of the peptide neurohormones by the supraoptic nuclei was found in two hypertensive strains (SHR and ISIAH) compared to the normotensive Wistar rats. For ISIAH-rats, the excretion of neurohormones was more pronounced in the region of median eminence, and for SHR--in the posterior hypophyseal lobe. It was concluded that hyperfunction of HHNS can play an important role in the hypertension development in two strains or rats studied.

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