Correlation between reproductive and interfering activities of epidemic and thermosensitive influenza virus strains
Aleksandrova, G.I.; Dekhtyareva, N.I.; Medvedeva, T.E.; Shneider, M.A.
Acta Virologica 26(3): 113-118
1982
ISSN/ISBN: 0001-723X PMID: 6127010 Document Number: 183631
Differences in interfering activities were demonstrated between low-passage epidemic and thermosensitive cold-adapted strains of influenza viruses A and B in experiments on chick embryos inoculated on the chorioallantoic membranes and on white mice. At a high multiplicity of infection the thermosensitive variants showed a higher interfering activity as compared with the original viruses which had undergone a limited number of chick embryo passages.
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