Effect of armin and dipyroxime on the nicotinamide coenzyme and adenine nucleotide content of the rat myocardium and liver
Tikhonenko, V.M.
Farmakologiia i Toksikologiia 45(1): 26-29
1982
ISSN/ISBN: 0014-8318 PMID: 7056378 Document Number: 183478
It has been shown in rat experiments that armin in doses that inhibit blood cholinesterase by 50 and more per cent lowers the content of nicotinamide coenzymes in the myocardium and liver of the animals, primarily at the expense of the diminution of the oxidized forms. In the rat liver, armin decreases the content of adenyl nucleotides, mainly at the expense of ATP. Dipyroxime prevents changes induced by armin, which is accompanied by partial reactivation of cholinesterase. It is suggested that in the mechanism of antidote action of dipyroxime, of importance is its normalizing effect on redox and energy processes in the body.