Anti-arrhythmic action of adenosine and the cyclic nucleotide content of the myocardium of rats with ischemia
Eliseev, V.V.; Poltavchenko, G.M.; Evdokimova, N.R.; Sokolova, E.N.; Ovchinnikova, A.G.
Biulleten' Eksperimental'noi Biologii i Meditsiny 104(7): 43-45
1987
ISSN/ISBN: 0365-9615 PMID: 3040145 Document Number: 303695
In anesthetized rats a 30-min intravenous infusion of adenosine (2.5 mg/kg/min) performed after the coronary artery ligation significantly decreased the incidence and severity of early ischemic arrhythmias. After the infusion of adenosine, there was an increase in cGMP level in the left ventricular myocardium, cAMP content remained unchanged.