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Influence of triiodothyronine and insulin on liver adenine nucleotide levels in portal triad-clamping rats

Liu, P.; Wu, S.; Liu, Q.

Hunan Yi Ke da Xue Xue Bao 24(2): 113-115

1999

ISSN/ISBN: 1000-5625
PMID: 11938763
Document Number: 506840
To assess the influence of triiodothyronine(T3) and insulin on liver adenine nucleotide levels in portal triad-clamping rats. A rat model of normothermic portal triad clamping was established to observe the influence of T3 and insulin on the contents of liver adenine nucleotides and survival rates. The ATP levels and the 72 h-survival rate of T3 group were significantly higher than those of insulin group and saline group(P < 0.05). The blood glucose levels were obviously decreased and all the rats died within 6 hours postoperation in insulin group. T3 can improve hepatic energy metabolism after portal triad clamping and increase survival rate, whereas such effects were not found in insulin group.

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