Excretion of methoxychlor in cow milk following dermal application
Skaare, J.U.; Berge, G.; Odegaard, S.; Grave, K.
Acta Veterinaria Scandinavica 23(1): 16-23
1982
ISSN/ISBN: 0044-605X PMID: 7113866 Document Number: 182756
The concentrations of methoxychlor in cow milk and plasma were determined following a cutaneous application of a noncommercial emulsion and an i.v. injection of a solution containing 5 and 1 g methoxychlor, respectively. Some pharmacokinetic parameters were estimated and the results were evaluated toxicologically by comparison with the acceptable daily intake. Maximum concentration of methoxychlor in milk 2 days after dermal administration was 0.052 ppm, decreasing to .apprx. 0.005 ppm 30 days later. A distribution volume > 200 times the body volume, a dermal absorption of .apprx. 1/5 of the topically applicated dose and a half-life of 8-10 days were determined. The levels in cow milk following dermal application with an emulsion of methoxychlor did not represent any threat to human health and methoxychlor was recommended as a pesticide of choice for use on dairy cows.