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Studies of excretion in rabbit milk after administration of carbon-14 labelled amitriptyline and nortriptyline

Aaes-Jorgensen, T.; Jorgensen, A.

Archives Internationales de Pharmacodynamie et de Therapie 227(2): 294-301

1977

ISSN/ISBN: 0003-9780
PMID: 907414
Document Number: 117447
Excretion with rabbit milk was investigated after s.c. administration of 14C-labeled amitriptyline and nortriptyline. Amounts of drug material in suckling neonates from nursing rabbits dosed repeatedly with the 2 drugs were measured. Radioactivity concentrations in milk were of the same size as concentrations in serum. The radioactivity concentrations in organs of neonates, which had received milk from rabbits dosed for 5 days with amitriptyline or nortriptyline, were considerably below those found in corresponding organs of the dam. Amitriptyline administration to dams seeded to lead to higher concentrations in organs of offspring than did nortriptyline administration.

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