Drug uptake by lung slices from paraquat-pretreated rats
Drew, R.; Siddik, Z.S.
Experientia 37(10): 1093-1095
1981
ISSN/ISBN: 0014-4754 PMID: 7308402 Document Number: 180391
Lung slices from male Sprague-Dawley rats pretreated with paraquat (PQ) (100 .mu.mol .cntdot. kg-1, i.v.) 16 h before sacrifice, accumulated less PQ in vitro than lung slices from saline-treated controls. Neither lung slices from PQ-pretreated nor saline control animals released (effluxed) PQ accumulated in vitro. The accumulation and efflux of imipramine and 5-hydroxytryptamine by lung slices was unaffected by prior in vivo administration of PQ.
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