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Augmentation of specific cell-mediated immune responses to tumor cells in tumor-bearing rats pretreated wih the antileukemia drug busulfan

Mizushima, Y.; Sendo, F.; Miyake, T.; Kobayashi, H.

Journal of the National Cancer Institute 66(4): 659-665

1981

ISSN/ISBN: 0027-8874
PMID: 6939913
Document Number: 175210
Lethal growth of a syngeneic transplanted tumor ( serum and guinea pig complement. Augmentation of the immune response to KMT-17-associated antigen(s) in BU-pretreated TBR was also demonstrated in lymphocyte-mediated cytotoxicity; it was detected by a 51Cr release assay and by a delayed-type hypersensitivity with a radioisotope footpad assay. Tumor regression in BU-pretreated rats was demonstrated to be mediated by the augmentation of T cell-mediated immune responses to tumor-associated antigens. The tumor inhibitory effect of BU was abrogated by adoptive transfer with thymus cells from normal rats, but not with those from BU-pretreated rats 1 day before tumor inoculation. The augmentation of the antitumor immune responses by pretreatment with BU may be because BU selectively inhibited the suppressor cells or their precursors.

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