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Plasma and tissue concentrations of oxytetracycline in the horse after intravenous administration

Larson, V.L.; Stowe, C.M.

American Journal of Veterinary Research 42(12): 2165-2166

1981

ISSN/ISBN: 0002-9645
PMID: 7340586
Document Number: 180238
Oxytetracycline (OTC) was administered IV to 3 clinically normal horses at a dosage of 10 mg of OTC/kg of body weight. Plasma OTC concentrations were determined at 30-minute intervals until postinjection minute (PIM) 240. At PIM 240, the mean OTC concentration in pulmonary tissue was 3.96 microgram/g of tissue (wet weight) and in renal tissue was 25.47 micrograms/g. diluted bronchial fluid had a mean concentration of 0.288 microgram of OTC/ml at PIM 240. The data demonstrated that OTC has adequate tissue distribution in horses.

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