Plasma digoxin concentrations during administration of dietary fibre (guar gum) in man
Lembcke, B.; Häsler, K.; Kramer, P.; Caspary, W.F.; Creutzfeldt, W.
Zeitschrift für Gastroenterologie 20(3): 164-167
1982
ISSN/ISBN: 0044-2771 PMID: 6282000 Document Number: 194162
The effect of guar gum on digoxin absorption was investigated in eleven healthy volunteers. The drug was administered in the morning during two five-day-periods, together with a liquid mixed test meal (+/- 18 g guar). By measuring plasma digoxin concentrations no differences were registered between the control and guar gum period. It is concluded that long-term administration of guar gum will not interfere with adequate digitalization (digoxin bioavailability).
Document emailed within 1 workday
Related Documents
Haber, G.B.; Heaton, K.W.; Murphy, D.; Burroughs, L.F. 1977: Depletion and disruption of dietary fibre. Effects on satiety, plasma-glucose, and serum-insulin Lancet 2(8040): 679-682Lembcke, B.; Ebert, R.; Ptok, M.; Caspary, W.F.; Creutzfeldt, W.; Schicha, H.; Emrich, D. 1984: Role of gastrointestinal transit in the delay of absorption by viscous fibre (guar) Hepato-Gastroenterology 31(4): 183-186
Cargnelli, G.; Domeneghetti, F.; Ferrari, M.; Malacini, P.; Roberti, G. 1977: Plasma digoxin concentrations in patients with atrial fibrillation and indications for the association with other antiarrhythmic agents International Journal of Clinical Pharmacology and Biopharmacy 15(8): 384-388
Vemuri, S.; Barr, W.H.; Propert, D.B. 1992: A correlation between digoxin plasma concentrations and systolic time intervals in hospitalized congestive heart failure patients International Journal of Clinical Pharmacology Therapy and Toxicology 30(10): 388-393
Belz, G.G.; Rudofsky, G.; Lossnitzer, K.; Wolf, G.; Sauch, M. 1974: Plasma levels and electrocardiogram after intravenous administration of proscillaridin and digoxin Zeitschrift für Kardiologie 63(3): 201-211
Sheiner, L.B.; Halkin, H.; Peck, C.; Rosenberg, B.; Melmon, K.L. 1975: Improved computer-assisted digoxin therapy. A method using feedback of measured serum digoxin concentrations Annals of Internal Medicine 82(5): 619-627
Rick, A.D.; Belpaire, F.M.; Bogaert, M.G.; Mattheeuws, D. 1978: Plasma concentrations of digoxin and digitoxin during digitalization of healthy dogs and dogs with cardiac failure American Journal of Veterinary Research 39(5): 811-815
Ruggiero, M.; Perna, M.; Morelli, S.; Monaco, A.; Salvia, F.; Cantore, R.; Mangoni di S Stefano, C. 1981: Diurnal variations in plasma aminoacid concentrations. I) Effect of dietary protein intake on rhythm of neutral aminoacids Bollettino della Societa Italiana di Biologia Sperimentale 57(21): 2116-2122
Lee, Y-Mi.; Choi, M.Ja.; Chang, K.Ja. 2003: The effect of dietary taurine supplementation on plasma and urinary free amino acid concentrations in diabetic rats Advances in Experimental Medicine and Biology 526: 75-82
Areekul, S. 1973: Plasma volume changes following administration of different concentrations of dextran in dogs Southeast Asian Journal of Tropical Medicine and Public Health 4(2): 284
O'Keefe, S.J.; Ndaba, N.; Woodward, A. 1985: Relationship between nutritional status, dietary intake patterns and plasma lipoprotein concentrations in rural black South Africans Human Nutrition. Clinical Nutrition 39(5): 335-341
Larson, V.L.; Stowe, C.M. 1981: Plasma and tissue concentrations of oxytetracycline in the horse after intravenous administration American Journal of Veterinary Research 42(12): 2165-2166
Siegers, C.P.; Iven, H.; Strubelt, O. 1977: Plasma concentrations and renal excretion of vincamine after oral administration in man Arzneimittel-Forschung 27(6a): 1271-1274
Chillet, P.; Korach, J.M.; Petitpas, D.; Vincent, N.; Poiron, L.; Barbier, B.; Boazis, M.; Berger, P.H. 2002: Digoxin poisoning and anuric acute renal failure: efficiency of the treatment associating digoxin-specific antibodies (Fab) and plasma exchanges International Journal of Artificial Organs 25(6): 538-541
De Graves, F.J.; Riddell, M.G.; Schumacher, J. 1996: Ketoprofen concentrations in plasma and milk after intravenous administration in dairy cattle American Journal of Veterinary Research 57(7): 1031-1033
Willms, B.; Arends, J. 1987: Comparison of isolated (guar) and natural (Müsli) dietary fiber in the treatment of type Ii diabetes Medizinische Klinik 82(12-13): 429-431
Preston, A.M.; Bercovitch, F.B.; Jimenez, B.D.; Rodriguez Orengo, J.F.; Morales, W.Delgado.; Rodriguez, C.A.; Lebron, M.R.; Rivera, C.E. 2002: Plasma homocysteine concentrations in a population of rhesus monkeys (Macaca mulatta): reference ranges and accompanying plasma concentrations of folate and vitamin B12 Contemporary Topics in Laboratory Animal Science 41(1): 28-30
Wagner, J.G.; Welling, P.G.; Roth, S.B.; Sakmar, E.; Lee, K.P.; Walker, J.E. 1972: Plasma concentrations of propoxyphene in man. I. Following oral administration of the drug in solution and capsule forms Internationale Zeitschrift für Klinische Pharmakologie Therapie und Toxikologie. International Journal of Clinical Pharmacology Therapy and Toxicology 5(4): 371-380
Ayuso, M.A.; Moragas, M.; Marques, J.M.; Luis, M. 1986: Use of lidocaine by the topical route for the practice of indirect laryngoscopy. Study of plasma concentrations during and after its administration Revue de Laryngologie - Otologie - Rhinologie 107(2): 157-159
Dieterich, H.A.; Messer, W.; Jaehnchen, E. 1984: Plasma concentrations of theophylline and quinine in healthy volunteers following oral administration of a fixed drug combination Arzneimittel-Forschung 34(4): 520-522