Oxytetracycline plasma levels in dogs after intramuscular administration of two formulations
Immelman, A.; Dreyer, G.
Journal of the South African Veterinary Association 52(3): 191-193
1981
ISSN/ISBN: 1019-9128 PMID: 7310789 Document Number: 182366
Plasma levels of oxtetracycline in dogs were compared in a cross-over study. A long-acting formulation and a polyvinylpyrrolidone formulation were injected intramuscularly. Symptoms of histamine release were recorded after the use of the polyvinylpyrrolidone formulation. Higher peak plasma concentrations but shorter maintenance of therapeutic concentrations were recorded in the case of the polyvinylpyrrolidone formulation than with the long-acting formulation.