Concentration-time profiles of oxytetracycline in blood, kidney and liver of tench (Tinca tinca L) after intramuscular administration
Reja, A.; Moreno, L.; Serrano, J.M.; Santiago, D.; Soler, F.
Veterinary and Human Toxicology 38(5): 344-347
1996
ISSN/ISBN: 0145-6296 PMID: 8888537 Document Number: 465229
Oxytetracycline (OTC) concentrations were measured in plasma, kidney and liver in tench after i.m. administration (100 mg/kg) using HPLC. Concentrations were fitted to a monocompartment open model by extended least squares regression analysis using the MULTI (ELS) computer program. Peaks of OTC concentrations (Cmax) were reached at 4 h for blood and kidney and 72 h for liver and were 134.1 micro g/ml, 129.8 micro g/g and 333.4 micro g/g, respectively. There was a high correlation (r=0.9448) between blood and kidney concentrations and less between blood and liver. Concentrations were statistically different for each system. The blood OTC concentrations were higher than renal concentrations 92% of the time and were higher than hepatic concentrations 29% of the time. The plasma OTC half-life (21.2 h) was longer than in homeothermic species. The tench liver retains high OTC residues which may affect food products.