Clindamycin levels in the cervical mucus after intramuscular administration of the drug
Creatsas, G.; Pavlatos, M.; Lolis, D.; Kaskarelis, D.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction 8(5): 441-443
1979
ISSN/ISBN: 0368-2315 PMID: 541482 Document Number: 153119
Female genital tract is a major area of anaerobic infections. Clindamycin has been used as a highly active antibiotic against both gram positive and negative anaerobic pathogens including bacteroides fragilis. Concentration of clindamycin in cervical mucus has been tested in 30 women after administration of one single dose (600 mg) of the antibiotic intramuscularly. Antibiotic levels were tested by agar diffusion method employing a strain of alpha-hemolytic streptococcus. Levels of clindamycin in cervical mucus were found to be sufficient to inhibit "in vitro" a significant proportion of anaerobic bacteria present in cervical mucus.