Effect of nerobolil on higher fatty acid metabolism in the rat liver normally and in disordered protein metabolism
Matiushin, I.F.; Boiarinov, G.A.; Bogdarin, I.A.
Voprosy Meditsinskoi Khimii 27(5): 604-607
1981
ISSN/ISBN: 0042-8809 PMID: 7314574 Document Number: 173130
Metabolism of fatty acids in rat liver tissue and content of albumin in blood of control rats as well as in the animals with impaired protein metabolism as a result of thermic trauma were studied under conditions of nerobolyl treatment (5 mg per kg of body mass within a day) of different duration. After daily administration of the drug (within 13 days) into control rats and into the animals with burns, content of oleic and linoleic acids was decreased in liver tissue but the content of 5,8,11-eicosatrienic acid and total monoenic acids with uneven amount of carbon atoms was increased with simultaneous decrease in albumin concentration in blood. Metabolism of fatty acids was altered only slightly in liver tissue of healthy animals after nerobolyl administration within three weeks (with an interval for 3-4 days); under conditions of the thermic trauma nerobolyl normalized the fatty acids metabolism in liver tissue and increased the albumin content in blood.