Effect of glucose utilization inhibitor isolated from the serum and urine of patients with chronic renal failure on the free fatty acid metabolism in rat kidney cortex slices

Chorváthová, V.; Dzúrik, R.; Ondreicka, R.; Ozdín, L.; Nemec, R.; Cerveń, J.

Physiologia Bohemoslovaca 25(2): 123-127

1976


ISSN/ISBN: 0369-9463
PMID: 131346
Document Number: 105625
The authors studied interference by the inhibitor of glucose utilization with free fatty acid (FFA) metabolism in rat kidney cortex slices. They found that FFA uptake by the kidneys, their incorporation into triglycerides (TG) and oxidation to 14CO2 were lower when the inhibitor was present in the incubation medium. The findings show that the inhibitor, as well as inhibiting glucose utilization in various tissues, interferes directly with fat metabolism.

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