Age-related features of the metabolism of fatty acid components of phospholipids of the cell nuclei of rat liver under the effect of dietetic factors
Babenko, N.A.
Ukrainskii Biokhimicheskii Zhurnal 61(3): 85-90
1989
ISSN/ISBN: 0201-8470 PMID: 2749917 Document Number: 345728
The metabolism of nuclear phospholipid acyl components of liver in uneven-aged rats was studied in vitro under different dietary fat implications. The activity of phospholipases A1 and A2 in the nuclei was found to sharply increase in animals pretreated with excess of fat. The incorporation of labelled palmitic, oleic, linoleic and arachidonic acid into nuclear phospholipids is under control of age and diet manipulations. The observed changes in the level of fatty acids metabolism are more pronounced in cell nuclei of the young rat liver. The lipid composition of cell nuclei in the test 3-month old animals does not differ from that of the control animals. At the same time dietary implications induce deep changes in the composition of nuclear lipids in 24-months old animals.